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Symbol Name ID |
Ercc1
excision repair cross-complementing rodent repair deficiency, complementation group 1 MGI:95412 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | Increased circulating IgA level |
Increased circulating IgG level |
Decreased circulating antibody level |
Paraproteinemia |
Anemia |
Acute lymphoblastic leukemia |
T-cell acute lymphoblastic leukemias |
Acute myeloid leukemia |
Lymphoma |
Multiple myeloma |
Splenomegaly |
Hepatosplenomegaly |
| Disease(s) Associated with ERCC1 | ||||||||||||
| acute lymphoblastic leukemia | ||||||||||||
| acute myeloid leukemia | ||||||||||||
| multiple myeloma | ||||||||||||
| pancreatic cancer |
| Mouse Phenotypes | hematopoietic system phenotype |
decreased B cell proliferation |
decreased common myeloid progenitor cell number |
abnormal class switch recombination |
decreased granulocyte monocyte progenitor cell number |
decreased erythroid progenitor cell number |
decreased hematopoietic stem cell number |
decreased megakaryocyte-erythroid progenitor cell number |
abnormal spleen morphology |
spleen hypoplasia |
|
| Availability | Mouse Genotype | ||||||||||
| Ercc1tm1Jhjh/Ercc1tm1Jhjh | |||||||||||
| Ercc1tm2Jhjh/Ercc1tm2Jhjh | |||||||||||
| Ercc1tm1Jhjh/Ercc1tm2Jhjh | |||||||||||
| Ercc1tm1Jhjh/Ercc1tm3Jhjh Tg(Tek-cre)12Flv/0 (conditional) |
* | ||||||||||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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